If you only borrow one method from this list, this is the one with the deepest track record. The Norwegian 4×4 is the most-studied interval format for raising VO2 max, and the beauty of it is how portable the structure is.
How It Works and Why
The idea is simple: work hard for four minutes, recover easy for three, and repeat that four times. Those long, near-maximal efforts keep your heart filling and emptying at a high rate long enough to stretch its pumping capacity, which is the central adaptation behind a rising VO2 max. In the 2007 trial published in Medicine & Science in Sports & Exercise, around 40 moderately trained men did 4 × 4-minute intervals at roughly 90 to 95 percent of their maximum heart rate, with three-minute active recovery near 70 percent, three times a week for eight weeks. Their VO2 max climbed about 7 percent, beating moderate steady jogging of the same total workload. Some later analyses report bigger jumps, but 7 percent is the well-replicated, honest expectation.
The protocol is potent enough that it's been used well beyond healthy athletes. In a supervised trial of people with stable heart failure, an interval group following the same 4×4 template improved VO2 max dramatically more than a moderate-exercise group, a striking result reported in Circulation. Those patients trained under medical oversight, so it's a demonstration of the method's power rather than a home benchmark, but it tells you the engine is real.
Your At-Home Version
You don't need a treadmill. Pick any movement that lets you push your heart rate up and hold it there: jogging in place with high knees, running up and down a stairwell, fast jumping jacks, shadow-boxing, or skipping rope.
A session at a glance: warm up for 5 to 10 minutes, then go four minutes at a hard effort where talking is down to a word or two (about an 8 or 9 out of 10), ease off for three minutes of gentle marching or slow stepping, and repeat until you've done four hard blocks. A five-minute cool-down closes it out, for roughly 35 minutes total.
If four minutes at that intensity feels like too much at first, you might shorten the hard piece to two or three minutes and build up, or drop to three rounds instead of four. The goal is to finish each hard block feeling like you had maybe 30 seconds left in the tank, not to bury yourself.